Background: INFLAMMATORY pseudotumor (IPT) is a benign lesion with potential of recurrence and continuous growth. Its clinical and pathologic features resemble malignancies. The present study was conducted in Shaheed Beheshti University of Medical Sciences to determine the status of IPT. Materials and methods: During this descriptive study, the pathology reports of Shaheed Beheshti university teaching hospitals were reviewed from early 1993 to the end of 1998 and 20 cases of INFLAMMATORY pseudotumor were found. Results: The study population included 12 females and 8 males with the mean age of 20 years. 8 cases (40%) were occurred in lung, whereas 12 (60%) were in extra pulmonary regions. 16 had anemia, whereas weight loss and anorexia were reported in 7 cases (35%). Most of the adults had undergone operation with preoperative diagnosis of malignant tumor, however, most of the children received treatment with the probable diagnosis of recurrent pneumonia. Conclusion: Since wide spectrums of benign and malignant tumors are considered as IPT differential diagnosis, suitable preoperative studies such as immunohistochemistry and flowcytometery are highly recommended.

This study investigated the presence of mast CELLS in INFLAMMATORY aural polyp using light microscopy. The number of mast CELLS was increased in all examined cases and varied from 2.33to 41.54 per mm2.The CELLS were located most commonly around small blood vessels. Occurrence of mast CELLS was not different in various; types of polyps, but their density was severely increased in active in flamed polypous; tissue. These findings suggest that mast CELLS may be a contributory factor in the: pathogenesis of middle ear INFLAMMATORY processes.

Inflammation is not only a protective mechanism during tissue injury, but also has a key role in tissue repair.Cytokines and growth factors which are released during inflammation are critical for tissue repair and one of the well-known angiogenic factors is vascular endothelial growth factor. Angiogenesis involves endothelial CELLS as well as INFLAMMATORY CELLS which release several angiogenic factors. Hypoxia is the most important stimulator for inflammation and angiogenesis. Some of the INFLAMMATORY mediators are directly and/or indirectly alter angiogenesis and on the other hand, some of angiogenic factors have INFLAMMATORY effects. Therefore, it seems that there is a close relationship between angiogenesis and inflammation. This review evaluated the relationship between inflammation and angiogenesis and the role of INFLAMMATORY CELLS and mediators in angiogenesis process.

CD4+T CELLS are composed of different subpopulations that differ in developmental pathways, surface markers, and their products. Among the catalog of these CELLS is Th9 cell subset that has a great capacity of Interleukin (IL)-9 production. They could be involved in the pathogenic or protective immune responses. Therefore, it is important to know how Th9 CELLS and cytokines influence the function of the human immune system as multitasking machinery, both in isolation or after the interaction with other surrounding CELLS. Since an important characteristic of Th9 CELLS is their tropism for skin, this article reviews the physiological and pathophysiological functions of Th9 and its cytokines under normal conditions and INFLAMMATORY skin disorders.